ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeP739H

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: mutations in DNA gyrase subunit B (GyrB D429N and P739H) and topoisomerase IV subunit E (ParE P456S) during in vitro selection
Resistance To: ciprofloxacin
Organisms: Neisseria canis
Papers: 2

Paper Information2

In vitro evolution of ciprofloxacin resistance in Neisseria commensals and derived mutation population dynamics in natural Neisseria populations.

GyrB P739H mutation was associated with intermediate ciprofloxacin resistance in gonococci.

Protein Change: P739H
Organisms: Neisseria canis
Confers Resistance To: ciprofloxacin
Validation Method: whole genome sequencing and MIC testing; experimental evolution and MIC testing
Source Database: Reslit

In vitro evolution of ciprofloxacin resistance in Neisseria commensals and derived mutation population dynamics in natural Neisseria populations.

Protein Change: P739H
Organisms: Neisseria canis
Confers Resistance To: ciprofloxacin
Effect on Function: mutations in DNA gyrase subunit B (GyrB D429N and P739H) and topoisomerase IV subunit E (ParE P456S) during in vitro selection
Validation Method: whole genome sequencing
Source Database: Reslit

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