ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT80I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased affinity for ciprofloxacin
Resistance To: fluoroquinolones, ciprofloxacin
Organisms: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Campylobacter, Neisseria gonorrhoeae +1 more
Papers: 2

Paper Information2

Eradication of Helicobacter pylori reshapes gut microbiota and facilitates the evolution of antimicrobial resistance through gene transfer and genomic mutations in the gut.

PMID 40000989 · 2025

Genomic mutations in gyrA contributed to resistance to nalidixic acid and ciprofloxacin.

Mutation Information

gyrA: p.T80I

Protein Change: T80I
Organisms: Escherichia coli, Klebsiella pneumoniae
Confers Resistance To: fluoroquinolones
Validation Method: whole genome sequencing
Source Database: Reslit

The resistance mechanisms of bacteria against ciprofloxacin and new approaches for enhancing the efficacy of this antibiotic.

PMID 36620240 · 2022

Mutation Information

gyrA: p.T80I / c.A240G

Protein Change: T80I
Nucleotide Change: A240G
Organisms: Escherichia coli, Pseudomonas aeruginosa, Campylobacter, Neisseria gonorrhoeae, Neisseria meningitidis
Confers Resistance To: ciprofloxacin
Effect on Function: decreased affinity for ciprofloxacin
Validation Method: sequencing and mutation analysis
Source Database: Reslit

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