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Browse Mutations mmpL5Q196M

membrane transporter

Protein ChangeQ196M

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increases bedaquiline efflux
Resistance To: bedaquiline
Organisms: Mycobacterium tuberculosis, Mycobacterium marinum
Papers: 1

Paper Information1

1

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages increased bedaquiline resistance.

PMID 40986343 · 2025

Mutations identified in MmpL5 that increase bedaquiline efflux.

Mutation Information

Protein Change: Q196M
Organisms: Mycobacterium tuberculosis, Mycobacterium marinum
Confers Resistance To: bedaquiline
Effect on Function: increases bedaquiline efflux
Validation Method: genetic analysis and MIC testing
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research