ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeP527S

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Paper Information2

Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa.

Mutations in the PB domain of ftsI reduce carbapenem susceptibility while increasing susceptibility to cefiderocol and piperacillin.

Protein Change: P527S
Confers Resistance To: carbapenems
Validation Method: broth microdilution and growth parameter analysis; Antimicrobial susceptibility testing and molecular modeling
Source Database: Reslit

Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone.

ftsI

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