Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
penicillin-binding protein 3
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| N526K | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae, Streptococcus pyogenes, Streptococcus pneumoniae | ampicillin|amoxicillinampicillin|amoxicillin clavulanic acidampicillin|cefotaxime+8 more | ReslitReference Gene Catalog | Candidate | |
| D350N | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|amoxicillinampicillin|amoxicillin clavulanic acidampicillin|cefotaxime+4 more | ReslitReference Gene Catalog | Candidate | |
| M377I | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|amoxicillinampicillin|cefotaximeampicillin|amoxicillin clavulanic acid+5 more | ReslitReference Gene Catalog | Candidate | |
| A502V | - | Haemophilus influenzae | ampicillin|amoxicillinampicillin|cefotaximeampicillin+2 more | Reslit | Candidate | |
| S357N | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae, non-typeable Haemophilus | ampicillin|amoxicillinampicillin|cefotaximeampicillin|amoxicillin clavulanic acid+4 more | ReslitReference Gene Catalog | Candidate | |
| S385T | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|amoxicillinampicillin|cefotaximeampicillin|amoxicillin clavulanic acid+6 more | ReslitReference Gene Catalog | Candidate | |
| R517H | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|amoxicillinampicillin|cefepimeampicillin|cefotaxime+7 more | ReslitReference Gene Catalog | Candidate | |
| T532S | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae, non-typeable Haemophilus | ampicillin|amoxicillinampicillin|cefotaximecefuroxime+2 more | ReslitReference Gene Catalog | Candidate | |
| V547I | - | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acidampicillin|cefotaximeampicillin+2 more | Reslit | Candidate | |
| N569S | - | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acidampicillin|cefotaximeampicillin+2 more | Reslit | Candidate | |
| V511A | - | - | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acidampicillin|cefotaxime | Reslit | Candidate |
| A515V | - | increased binding affinity and sequestration of meropenem, penicillin-binding protein PBP3 FtsI | Acinetobacter baumannii | meropenemcarbapenems|sulbactam durlobactam | ReslitReference Gene Catalog | Candidate |
| R504C | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | ceftazidime|meropenem|aztreonamceftazidimemeropenem+4 more | ReslitReference Gene Catalog | Candidate |
| R504H | - | - | Pseudomonas aeruginosa | ceftazidime|meropenem|aztreonamceftazidimeaztreonam | Reslit | Candidate |
| P527T | - | - | Pseudomonas aeruginosa | ceftazidime|meropenem|aztreonamcarbapenems | Reslit | Candidate |
| F533L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | ceftazidime|meropenem|aztreonamcarbapenemsceftolozane tazobactam+2 more | ReslitReference Gene Catalog | Candidate |
| S412F | - | - | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| I532L | - | - | Escherichia coli | ceftazidime|ceftolozane tazobactam|cefepime|aztreonam | Reslit | Candidate |
| E349K | - | - | Escherichia coli | ceftazidime|ceftolozane tazobactam|cefepime|aztreonamcefiderocolceftolozane tazobactam | Reslit | Candidate |
| V329I | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| A368T | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximebeta lactams | ReslitReference Gene Catalog | Candidate |
| A388V | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| L389F | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximeampicillin|amoxicillin clavulanic acidcefoxitin|cefotaxime|cefdinir|cefprozil|ceftriaxone|ampicillin|imipenem|meropenem+5 more | ReslitReference Gene Catalog | Candidate | |
| P393L | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| A437S | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximebeta lactamsampicillin|penicillin | ReslitReference Gene Catalog | Candidate | |
| I449V | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximeampicillinbeta lactams+1 more | ReslitReference Gene Catalog | Candidate | |
| G490E | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximeampicillin|amoxicillinampicillin+2 more | ReslitReference Gene Catalog | Candidate | |
| I491V | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| R501L | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| A502S | - | - | - | ampicillin|cefotaxime | Reslit | Candidate |
| A502T | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximeampicillincephalosporins+1 more | ReslitReference Gene Catalog | Candidate | |
| I519L | - | Haemophilus influenzae | ampicillin|cefotaximeampicillin|penicillin | Reslit | Candidate | |
| A530S | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaximeimipenemampicillin+2 more | ReslitReference Gene Catalog | Candidate | |
| G555E | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|cefotaxime|cefiximebeta lactams | ReslitReference Gene Catalog | Candidate |
| Y557H | - | penicillin-binding protein PBP3 FtsI | non-typeable Haemophilus, Haemophilus influenzae | ampicillin|cefotaxime|cefiximecefoxitin|cefotaxime|cefpodoxime|ceftriaxonecefuroxime+1 more | ReslitReference Gene Catalog | Candidate |
| V523M | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | ceftazidimecarbapenems | ReslitReference Gene Catalog | Candidate |
| Q227H | - | - | Escherichia coli | aztreonam|ceftazidime avibactam|cefiderocolceftolozane tazobactam | Reslit | Candidate |
| E353K | - | - | Escherichia coli | aztreonam|ceftazidime avibactam|cefiderocol | Reslit | Candidate |
| I536L | - | - | Escherichia coli | aztreonam|ceftazidime avibactam|cefiderocol | Reslit | Candidate |
| A417V | - | - | Escherichia coli | aztreonam|ceftazidime avibactam|cefiderocol | Reslit | Candidate |
| L139R | - | - | Escherichia coli | aztreonam|ceftazidime avibactam | Reslit | Candidate |
| N366Y | - | - | Escherichia coli | aztreonam|ceftazidime avibactam | Reslit | Candidate |
| T322I | - | - | Haemophilus influenzae | ampicillin|cefotaxime|ceftriaxone | Reslit | Candidate |
| A370D | - | - | Corynebacterium striatum | beta lactams | Reslit | Candidate |
| V471G | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbenicillin|cefuroxime|doripenemdoripenemcarbapenems+1 more | ReslitReference Gene Catalog | Candidate |
| G63C | - | - | Pseudomonas aeruginosa | meropenem | Reslit | Candidate |
| L89V | - | - | - | carbapenems | Reslit | Candidate |
| M460T | - | - | - | carbapenems | Reslit | Candidate |
| P527S | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | ReslitReference Gene Catalog | Candidate |
| V537L | - | - | Pseudomonas aeruginosa | carbapenemsmeropenem|ceftazidime|ticarcillin | Reslit | Candidate |
| Y103D | - | - | Haemophilus parasuis, E. coli | cefaclor | Reslit | Candidate |
| N526H | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acidcephalosporins | ReslitReference Gene Catalog | Candidate |
| N117S | - | - | Pseudomonas aeruginosa | ceftazidime avibactam | Reslit | Candidate |
| H517R | - | - | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acid | Reslit | Candidate |
| K526N | - | - | Haemophilus influenzae | ampicillin|amoxicillin clavulanic acid | Reslit | Candidate |
| A413V | - | - | - | cefoxitin|cefotaxime|cefpodoxime|ceftriaxone|cephalexin|phenicols|ciprofloxacin|erythromycin|levofloxacin|linezolid|nitrofurantoin|penicillin|tetracycline|trimethoprimceftolozane tazobactam | Reslit | Candidate |
| A413T | - | - | - | cefoxitin|cefotaxime|cefpodoxime|ceftriaxone|cephalexin|phenicols|ciprofloxacin|erythromycin|levofloxacin|linezolid|nitrofurantoin|penicillin|tetracycline|trimethoprim | Reslit | Candidate |
| A62S | - | - | - | imipenem | Reslit | Candidate |
| L124I | - | - | - | imipenem | Reslit | Candidate |
| K127T | - | - | - | imipenem | Reslit | Candidate |
| N526L | - | - | - | imipenem | Reslit | Candidate |
| N789S | - | - | Pseudomonas aeruginosa | penicillin | Reslit | Candidate |
| D569S | - | - | Haemophilus influenzae | ampicillin | Reslit | Candidate |
| V239A | - | - | Pseudomonas aeruginosa | aztreonam | Reslit | Candidate |
| R351H | - | - | Helicobacter cinaedi | amoxicillin | Reslit | Candidate |
| E419K | - | - | Helicobacter cinaedi | amoxicillin | Reslit | Candidate |
| V562L | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | ampicillincephalosporins | ReslitReference Gene Catalog | Candidate |
| Y528H | - | - | Haemophilus influenzae, Escherichia coli | ampicillin|amoxicillin | Reslit | Candidate |
| N422I | - | - | Haemophilus influenzae | cefotaxime | Reslit | Candidate |
| A539T | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | ceftolozane tazobactamcarbapenems | ReslitReference Gene Catalog | Candidate |
| E149D | - | - | - | ceftolozane tazobactam | Reslit | Candidate |
| T233A | - | - | - | ceftolozane tazobactam | Reslit | Candidate |
| V332I | - | - | - | ceftolozane tazobactam | Reslit | Candidate |
| G63D | - | - | Pseudomonas aeruginosa | imipenem|ceftazidime|cefepime|piperacillin|tazobactam|piperacillin tazobactam | Reslit | Candidate |
| I332V | - | - | - | cefepime | Reslit | Candidate |
| T526S | - | penicillin-binding protein PBP3 FtsI | Acinetobacter baumannii | sulbactam durlobactam | Reference Gene Catalog | Candidate |
| R335RVPYR | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | cephalosporins | Reference Gene Catalog | Candidate |
| I336IKYRI | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | aztreonam|cefiderocol|cephalosporins | Reference Gene Catalog | Candidate |
| I336IPYRI | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | aztreonam | Reference Gene Catalog | Candidate |
| N337NYRIN | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | aztreonam|cefiderocol|cephalosporins | Reference Gene Catalog | Candidate |
| L350F | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| G363S | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| G363V | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| S365Y | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| A498T | - | penicillin-binding protein PBP3 FtsI | Escherichia coli | cephalosporins | Reference Gene Catalog | Candidate |
| V329A | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | cephalosporins | Reference Gene Catalog | Candidate |
| A337V | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | beta lactams | Reference Gene Catalog | Candidate |
| T443A | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | cephalosporins | Reference Gene Catalog | Candidate |
| K527N | - | penicillin-binding protein PBP3 FtsI | Haemophilus influenzae | cephalosporins | Reference Gene Catalog | Candidate |
| V355G | - | penicillin-binding protein PBP3 FtsI | Klebsiella pneumoniae | ceftibuten|ceftibuten avibactam | Reference Gene Catalog | Candidate |
| L367Q | - | penicillin-binding protein PBP3 FtsI | Klebsiella pneumoniae | ceftazidime avibactam | Reference Gene Catalog | Candidate |
| G63S | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| Y367C | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| S368L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| H394R | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| A419G | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| N427L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| N427S | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| L434V | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| A454V | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| Q458R | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| L461V | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| Q475R | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| R504L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| F507L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| V523A | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| S538L | - | penicillin-binding protein PBP3 FtsI | Pseudomonas aeruginosa | carbapenems | Reference Gene Catalog | Candidate |
| - | - | - | cephalosporins | Reslit | Candidate | |
| - | - | - | cefepime | Reslit | Candidate | |
| P408S | - | Haemophilus influenzae | ampicillin|penicillin | Reslit | Candidate | |
| R501C | - | Haemophilus influenzae | ampicillin|penicillin | Reslit | Candidate | |
| V412M | - | - | cefotaxime | Reslit | Candidate | |
| A586S | - | - | ampicillin|amoxicillin | Reslit | Candidate | |
| - | - | Pseudomonas aeruginosa | meropenem | Reslit | Candidate | |
| V418A | - | Haemophilus influenzae | ampicillin|penicillin | Reslit | Candidate | |
| V461I | - | Haemophilus influenzae | ampicillin|penicillin | Reslit | Candidate | |
| S406G | - | Haemophilus influenzae | ampicillin|penicillin | Reslit | Candidate |
Low beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains are best detected by testing amoxicillin susceptibility by the broth microdilution method.
Polymorphism in ftsI gene and {beta}-lactam susceptibility in Portuguese Haemophilus influenzae strains: clonal dissemination of beta-lactamase-positive isolates with decreased susceptibility to amoxicillin/clavulanic acid.
Mutations in the ftsI gene are associated with decreased susceptibility to β-lactam antibiotics
Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection.
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The Versatile Mutational Resistome of Pseudomonas aeruginosa.
A Large-Scale Whole-Genome Comparison Shows that Experimental Evolution in Response to Antibiotics Predicts Changes in Naturally Evolved Clinical Pseudomonas aeruginosa.
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Recurrent Meningitis Caused by β-Lactamase-Positive Amoxicillin/Clavulanate-Resistant Non-Typeable Haemophilus influenzae in a Child with an Inner Ear Malformation: A Case Report.
Multiple amino acid substitutions in the penicillin-binding protein 3 (PBP3) encoded region ftsI gene transpeptidase domain.
Escherichia coli strains possessing a four amino acid YRIN insertion in PBP3 identified as part of the SIDERO-WT-2014 surveillance study.
The YRIN insertion in PBP3 reduces susceptibility to several β-lactam antibiotics.
Characterization of Haemophilus influenzae Strains with Non-Enzymatic Resistance to β-Lactam Antibiotics Caused by Mutations in the PBP3 Gene in the Czech Republic in 2010-2018.
Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.
A Hunt for the Resistance of Haemophilus influnezae to Beta-Lactams.
mutations in the ftsI gene encoding PBP3
High level non-carbapenemase carbapenem resistance by overlaying mutations of mexR, oprD, and ftsI in Pseudomonas aeruginosa.
Molecular and Drug Resistance Characteristics of Haemophilus influenzae Carried by Pediatric Patients with Adenoid Hypertrophy.
Mutations in ftsI gene encoding PBP3 are associated with beta-lactam resistance in H. influenzae.
Genetic and molecular characterization of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin.
Mutations in ftsI contribute to high-level ampicillin resistance in BLNAR strains.
Beta-lactam effects on mixed cultures of common respiratory isolates as an approach to treatment effects on nasopharyngeal bacterial population dynamics.
mutation in the ftsI gene
Emergence of high-level aztreonam-avibactam and cefiderocol resistance following treatment of an NDM-producing Escherichia coli bloodstream isolate exhibiting reduced susceptibility to both agents at baseline.
mutations in ftsI are associated with reduced susceptibility to ATM–AVI and FDC
Mutations leading to ceftolozane/tazobactam and imipenem/cilastatin/relebactam resistance during in vivo exposure to ceftazidime/avibactam in Pseudomonas aeruginosa.
Evolution of beta-lactam resistance causes fitness reductions and several cases of collateral sensitivities in the human pathogen Haemophilus influenzae.
Mutations in ftsI are associated with increased MICs for beta-lactam antibiotics.
Rapid acquisition of daptomycin resistance in a Corynebacterium striatum osteoarticular infection: case report and discussion on antimicrobial resistance.
The A370D substitution affects cell division and peptidoglycan synthesis.
Genetic approach to study the relationship between penicillin-binding protein 3 mutations and Haemophilus influenzae beta-lactam resistance by using site-directed mutagenesis and gene recombinants.
High potency of sequential therapy with only β-lactam antibiotics.
Genome evolution drives transcriptomic and phenotypic adaptation in Pseudomonas aeruginosa during 20 years of infection.
Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus influenzae.
Mutations in ftsI confer resistance to ampicillin and cefotaxime.
Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa.
Mutations in the PB domain of ftsI reduce carbapenem susceptibility while increasing susceptibility to cefiderocol and piperacillin.
Mechanisms of Cefiderocol Resistance in Carbapenemase-Producing Enterobacterales: Insights from Comparative Genomics.
The genomic configurations driving antimicrobial resistance and virulence in colistin resistant Pseudomonas aeruginosa from an Egyptian Tertiary Oncology Hospital.
Outbreak of a beta-lactam resistant non-typeable Haemophilus influenzae sequence type 14 associated with severe clinical outcomes.
The mutation in the ftsI gene encoding penicillin-binding protein (PBP) 3 was associated with high MIC-values of ampicillin, cefuroxime and cefotaxime.
Activity of Imipenem-Relebactam against a Large Collection of Pseudomonas aeruginosa Clinical Isolates and Isogenic β-Lactam-Resistant Mutants.
ftsI mutation contributes to resistance against ceftolozane-tazobactam and ceftazidime-avibactam.
Role of Horizontal Gene Transfer in the Development of Multidrug Resistance in Haemophilus influenzae.
Mutations in the transpeptidase region of ftsI contribute to resistance against extended-spectrum cephalosporins.
Matrine reverses the resistance of Haemophilus parasuis to cefaclor by inhibiting the mutations in penicillin-binding protein genes (ftsI and mrcA).
Characterization of Ceftriaxone-Resistant Haemophilus influenzae Among Korean Children.
mutations in ftsI gene associated with ceftriaxone resistance
Characteristics of Haemophilus influenzae invasive isolates from Portugal following routine childhood vaccination against H. influenzae serotype b (2002-2010).
Mutations in the ftsI gene were associated with reduced susceptibility to ampicillin.
Molecular epidemiology of nontypeable Haemophilus influenzae causing community-acquired pneumonia in adults.
Mutations in ftsI gene lead to beta-lactam resistance
High Prevalence of Group III-Like Mutations Among BLPACR and First Report of Haemophilus influenzae ST95 Isolated from Blood in China.
Mutations in ftsI were associated with beta-lactam resistance
Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals.
Haemophilus influenzae carriage and antibiotic resistance profile in Belgian infants over a three-year period (2016-2018).
Mutations in the ftsI gene were found in 81.0% of the strains.
Molecular characterization of multidrug-resistant non-typeable Haemophilus influenzae with high-level resistance to cefuroxime, levofloxacin, and trimethoprim-sulfamethoxazole.
Evolution of extended-spectrum β-lactamase-producing ST131 Escherichia coli at a single hospital over 15 years.
Imipenem heteroresistance but not tolerance in Haemophilus influenzae during chronic lung infection associated with chronic obstructive pulmonary disease.
mutations in ftsI gene associated with imipenem heteroresistance
Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines.
Genome analysis of a transmissible lineage of pseudomonas aeruginosa reveals pathoadaptive mutations and distinct evolutionary paths of hypermutators.
Ampicillin-resistant Haemophilus influenzae isolates in Geneva: serotype, antimicrobial susceptibility, and β-lactam resistance mechanisms.
Mutations in the ftsI gene are associated with ampicillin resistance in Haemophilus influenzae.
Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.
Mutations in Genes Encoding Penicillin-Binding Proteins and Efflux Pumps Play a Role in β-Lactam Resistance in Helicobacter cinaedi.
Single nucleotide polymorphisms in genes encoding penicillin-binding proteins in β-lactamase-negative ampicillin-resistant Haemophilus influenzae in Japan.
A novel PBP3 substitution in Haemophilus influenzae confers reduced aminopenicillin susceptibility.
The wild-type ftsI gene was susceptible to aminopenicillins.
Polymorphism of ftsI gene in Haemophilus influenzae and emergence of cefotaxime resistance in two Tunisian hospitals.
The mutation N422I was observed in the Hi15 strain and is associated with increased resistance to cefotaxime.
Evaluation of in vitro activity of ceftolozane/tazobactam and comparators against recent clinical bacterial isolates, and genomics of Pseudomonas aeruginosa, Klebsiella pneumoniae and Escherichia coli isolates that demonstrated resistance to ceftolozane/tazobactam: data from Kuwait and Oman.
Mutations in ftsI were identified in E. coli isolates.
Molecular epidemiology and antibiotic resistance profiles of invasive Haemophilus influenzae from Norway 2017-2021.
Mutations in ftsI (PBP3) contribute to reduced susceptibility to beta-lactams.
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
missense mutation
Penicillin-binding protein 3 sequence variations reduce susceptibility of Pseudomonas aeruginosa to β-lactams but inhibit cell division.
All mutations are in the catalytic domain of PBP3 and reduce susceptibility to various β-lactams.
Cefepime-taniborbactam activity against antimicrobial-resistant clinical isolates of Enterobacterales and Pseudomonas aeruginosa: GEARS global surveillance programme 2018-22.
associated with reduced susceptibility to cefepime-taniborbactam
In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017.
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Activity of Sulbactam-Durlobactam and Comparators Against a National Collection of Carbapenem-Resistant Acinetobacter baumannii Isolates From Greece.
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In vitro activity of sulbactam-durlobactam against carbapenem-resistant Acinetobacter baumannii and mechanisms of resistance.
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Modification of the penicillin-binding-protein 3 as a source of resistance to broad-spectrum cephalosporins in Escherichia coli.
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Characterization of Escherichia coli NDM isolates with decreased susceptibility to aztreonam/avibactam: role of a novel insertion in PBP3.
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Antimicrobial Activities of Aztreonam-Avibactam and Comparator Agents against Contemporary (2016) Clinical Enterobacteriaceae Isolates.
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Genetic Features Leading to Reduced Susceptibility to Aztreonam-Avibactam among Metallo-β-Lactamase-Producing Escherichia coli Isolates.
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The Growing Threat of NDM-Producing Escherichia coli With Penicillin-Binding Protein 3 Mutations in the United States-Is There a Potential Role for Durlobactam?
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Population Analysis of Escherichia coli Sequence Type 361 and Reduced Cefiderocol Susceptibility, France.
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Frequencies and mechanisms of mutational resistance to ceftibuten/avibactam in Enterobacterales.
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Selection and characterization of mutational resistance to aztreonam/avibactam in β-lactamase-producing Enterobacterales.
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Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime.
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Genomic Diversity and Antimicrobial Resistance of Haemophilus Colonizing the Airways of Young Children with Cystic Fibrosis.
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Conversion of leukotrienes A4 to C4 in cell-free systems.
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Prevalence of macrolide-non-susceptible isolates among β-lactamase-negative ampicillin-resistant Haemophilus influenzae in a tertiary care hospital in Japan.
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Detection of N526K-substituted penicillin-binding protein 3 conferring low-level mutational resistance to β-lactam antibiotics in Haemophilus influenzae by disc diffusion testing on Mueller-Hinton agar according to EUCAST guidelines.
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[Prosthesis for the partially edentulous jaw: a case with the remaining upper left 1st molar and lower 2d premolars, central and lateral incisors and lower left 3d molar].
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Cefotaxime-non-susceptibility of Haemophilus influenzae induced by additional amino acid substitutions of G555E and Y557H in altered penicillin-binding protein 3.
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Mutations in porin LamB contribute to ceftazidime-avibactam resistance in KPC-producing Klebsiella pneumoniae.
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Within-host whole genome analysis of an antibiotic resistant Pseudomonas aeruginosa strain sub-type in cystic fibrosis.
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Hypermutator Pseudomonas aeruginosa Exploits Multiple Genetic Pathways To Develop Multidrug Resistance during Long-Term Infections in the Airways of Cystic Fibrosis Patients.
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Penicillin-binding protein 3 is a common adaptive target among Pseudomonas aeruginosa isolates from adult cystic fibrosis patients treated with β-lactams.
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Deciphering the Resistome of the Widespread Pseudomonas aeruginosa Sequence Type 175 International High-Risk Clone through Whole-Genome Sequencing.
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Cellular calcium and atherosclerosis: a brief review.
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Evolution of the Pseudomonas aeruginosa mutational resistome in an international Cystic Fibrosis clone.
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Structural basis for effectiveness of siderophore-conjugated monocarbams against clinically relevant strains of Pseudomonas aeruginosa.
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Direct prediction of carbapenem resistance in Pseudomonas aeruginosa by whole genome sequencing and metagenomic sequencing.
ftsI
Evolution of Pseudomonas aeruginosa Antimicrobial Resistance and Fitness under Low and High Mutation Rates.
ftsI
National Danish surveillance of invasive clinical Haemophilus influenzae isolates and their resistance profile.
Mutations in ftsI gene associated with beta-lactam resistance.
Amino acid substitutions in PBP3 in Haemophilus influenzae strains, their phenotypic detection and impact on resistance to β-lactams.
Antibiotic Cycling Affects Resistance Evolution Independently of Collateral Sensitivity.
mutations in penicillin-binding domain associated with cefotaxime resistance