ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeN526H

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: penicillin-binding protein PBP3 FtsI
Resistance To: ampicillin|amoxicillin clavulanic acid, cephalosporins
Organisms: Haemophilus influenzae
Papers: 2

Paper Information2

High Prevalence of Group III-Like Mutations Among BLPACR and First Report of Haemophilus influenzae ST95 Isolated from Blood in China.

PMID 36824068 · 2023

Mutations in ftsI were associated with beta-lactam resistance

Mutation Information

ftsI: p.N526H

Protein Change: N526H
Organisms: Haemophilus influenzae
Confers Resistance To: ampicillin|amoxicillin clavulanic acid
Validation Method: sequencing
Source Database: Reslit

Evolution of mutations in the ftsI gene leading to amino acid substitutions in PBP3 in Haemophilus influenzae strains under the selective pressure of ampicillin and cefuroxime.

PMID 38954914 · 2024

ftsI

Mutation Information

ftsI: p.N526H

Protein Change: N526H
Organisms: Haemophilus influenzae
Confers Resistance To: cephalosporins
Effect on Function: penicillin-binding protein PBP3 FtsI
Source Database: Reference Gene Catalog

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