Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
High potency of sequential therapy with only β-lactam antibiotics.
Specific variants in ftsI reduce carbapenem susceptibility in Pseudomonas aeruginosa.
Mutations in the PB domain of ftsI reduce carbapenem susceptibility while increasing susceptibility to cefiderocol and piperacillin.
Penicillin-binding protein 3 sequence variations reduce susceptibility of Pseudomonas aeruginosa to β-lactams but inhibit cell division.
All mutations are in the catalytic domain of PBP3 and reduce susceptibility to various β-lactams.
A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical Pseudomonas aeruginosa.
ftsI
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