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Browse Mutations gyrAG83S

GenegyrA

Protein ChangeG83S

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of the water-magnesium ion bridge
Resistance To: ciprofloxacin
Organisms: Escherichia coli
Papers: 1

Paper Information1

1

Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

PMID 26984528 · 2016

Mutations were identified in E. coli strains selected under pressure of ciprofloxacin and Cip-DNP.

Mutation Information

Protein Change: G83S
Organisms: Escherichia coli
Confers Resistance To: ciprofloxacin
Effect on Function: disruption of the water-magnesium ion bridge
Validation Method: MIC testing in E. coli
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research