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Browse Mutations gyrBE466C

GenegyrB

Protein ChangeE466C

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: fluoroquinolones
Organisms: Escherichia coli, Mycobacterium smegmatis
Papers: 1

Paper Information1

1

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

PMID 24497635 · 2014

Mutations in GyrB contribute to fluoroquinolone resistance through cross-linking mechanisms.

Mutation Information

Protein Change: E466C
Organisms: Escherichia coli, Mycobacterium smegmatis
Confers Resistance To: fluoroquinolones
Validation Method: cross-linking experiments and EDTA reversal tests
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research