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Browse Mutations rhoG56C

Generho

Protein ChangeG56C

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduces susceptibility to cefuroxime by impairing RNA binding
Resistance To: cefuroxime
Organisms: Bacillus subtilis
Papers: 1

Paper Information1

1

Mutations in the Primary Sigma Factor σA and Termination Factor Rho That Reduce Susceptibility to Cell Wall Antibiotics.

PMID 25112476 · 2014

The rho G56C mutation reduces susceptibility to cefuroxime by impairing RNA binding.

Mutation Information

Protein Change: G56C
Organisms: Bacillus subtilis
Confers Resistance To: cefuroxime
Effect on Function: reduces susceptibility to cefuroxime by impairing RNA binding
Validation Method: genetic reconstruction and MIC assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research