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Browse Mutations gyrAY123F

GenegyrA

Protein ChangeY123F

Nucleotide ChangeA369T

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: fluoroquinolones
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

1

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

PMID 30757898 · 2019

The Y123F mutation in GyrA was studied in the context of gepotidacin's mechanism of action.

Mutation Information

gyrA: p.Y123F / c.A369T

Protein Change: Y123F
Nucleotide Change: A369T
Organisms: Staphylococcus aureus
Confers Resistance To: fluoroquinolones
Validation Method: structural studies with mutant GyrA
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research