ResLit - Antimicrobial Resistance Gene & Mutation Database

Nucleotide ChangeGAT->ATT

Validation StatusCandidate

Databases

Reslit

Overview

Paper Information2

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase.

Mutations in gyrA confer resistance to fluoroquinolones

Protein Change: S83I
Nucleotide Change: GAT->ATT
Organisms: E. coli
Confers Resistance To: fluoroquinolones
Validation Method: isolation and identification of E. coli mutants resistant to compound 1 and its analogs with mutations that mapped to this enzyme
Source Database: Reslit

Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae.

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