ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeD88G

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: DNA gyrase subunit A GyrA
Resistance To: ciprofloxacin|levofloxacin|moxifloxacin, levofloxacin|ciprofloxacin, quinolones
Organisms: Haemophilus influenzae, non-typeable Haemophilus
Papers: 2

Paper Information2

Molecular characterization of fluoroquinolones, macrolides, and imipenem resistance in Haemophilus influenzae: analysis of the mutations in QRDRs and assessment of the extent of the AcrAB-TolC-mediated resistance.

PMID 30145620 · 2018

gyrA

Mutation Information

gyrA: p.D88G

Protein Change: D88G
Organisms: Haemophilus influenzae
Confers Resistance To: ciprofloxacin|levofloxacin|moxifloxacinquinolones
Effect on Function: DNA gyrase subunit A GyrA
Validation Method: amino acid substitutions in GyrA (Ser84 and Asp88), ParC (Ser84), and ParE (Asp420)
Source Database: ReslitReference Gene Catalog

Molecular characterization of multidrug-resistant non-typeable Haemophilus influenzae with high-level resistance to cefuroxime, levofloxacin, and trimethoprim-sulfamethoxazole.

PMID 37407940 · 2023

Mutation Information

gyrA: p.D88G

Protein Change: D88G
Organisms: non-typeable Haemophilus
Confers Resistance To: levofloxacin|ciprofloxacin
Validation Method: genomic variation analysis
Source Database: Reslit

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