ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeK450T

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: single resistance variant, DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
Resistance To: zoliflodacin
Organisms: Neisseria gonorrhoeae
Papers: 1

Paper Information1

In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae.

PMID 31730160 · 2019

All resistant mutants contained these GyrB mutations.

Neisseria gonorrhoeae gyrB conferring resistance to zoliflodacin; CARD accession: CARD:3004859

gyrB

Mutation Information

gyrB: p.K450T

Protein Change: K450T
Organisms: Neisseria gonorrhoeae
Confers Resistance To: zoliflodacin
Effect on Function: single resistance variant; DNA topoisomerase (ATP-hydrolyzing) subunit B GyrB
Validation Method: selection-of-resistance studies
Source Database: ReslitCard DatabaseReference Gene Catalog

Comments (0)

No comments yet. Be the first to comment!

Mutation Information

Browse AMR Mutations

Mutation Information