ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeN499I

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: ofloxacin
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

Resistance-Conferring Mutations on Whole-Genome Sequencing of Fluoroquinolone-resistant and -Susceptible Mycobacterium tuberculosis Isolates: A Proposed Threshold for Identifying Resistance.

PMID 32348473 · 2021

Mutations in gyrA and gyrB are the most frequent mechanism of fluoroquinolone resistance.

Mutation Information

gyrB: p.N499I

Protein Change: N499I
Organisms: Mycobacterium tuberculosis
Confers Resistance To: ofloxacin
Validation Method: whole-genome sequencing and phenotypic resistance testing
Source Database: Reslit

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