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Browse Mutations penAR7K

GenepenA

penicillin-binding protein 2 (PBP 2)

Protein ChangeR7K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: no effect on PenA activity
Resistance To: ceftazidime|amoxicillin clavulanic acid
Organisms: Burkholderia pseudomallei
Papers: 1

Paper Information1

1

Molecular Investigations of PenA-mediated β-lactam Resistance in Burkholderia pseudomallei.

PMID 21747814 · 2011

Mutations in the TAT-signal sequence of PenA affect secretion and thus resistance.

Mutation Information

Protein Change: R7K
Organisms: Burkholderia pseudomallei
Confers Resistance To: ceftazidime|amoxicillin clavulanic acid
Effect on Function: no effect on PenA activity
Validation Method: engineered mutation
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research