ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeG85C

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: levofloxacin|moxifloxacin, fluoroquinolones
Organisms: Helicobacter pylori
Papers: 1

Paper Information1

Discovery of a Novel Mutation in DNA Gyrase and Changes in the Fluoroquinolone Resistance of Helicobacter pylori over a 14-Year Period: A Single Center Study in Korea.

PMID 32471292 · 2020

The Gly85Cys mutation was confirmed to be associated with fluoroquinolone resistance.

Helicobacter pylori gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3007052

Mutation Information

gyrA: p.G85C

Protein Change: G85C
Organisms: Helicobacter pylori
Confers Resistance To: levofloxacin|moxifloxacinfluoroquinolones
Effect on Function: single resistance variant
Validation Method: natural transformation and DNA sequencing
Source Database: ReslitCard Database

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