ResLit - Antimicrobial Resistance Gene & Mutation Database

GenegyrB

Protein ChangeS463A

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: quinolones, ciprofloxacin, fluoroquinolones
Organisms: Morganella morganii, Salmonella Typhimurium, Salmonella Enteritidis
Papers: 2

Paper Information2

Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene.

PMID 25106550 · 2014

Morganella morganii gyrB conferring resistance to fluoroquinolones; CARD accession: CARD:3003306

Mutation Information

gyrB: p.S463A

Protein Change: S463A
Organisms: Morganella morganii
Confers Resistance To: quinolonesfluoroquinolones
Effect on Function: single resistance variant
Validation Method: sequencing
Source Database: ReslitCard Database

High relatedness of invasive multi-drug resistant non-typhoidal Salmonella genotypes among patients and asymptomatic carriers in endemic informal settlements in Kenya.

PMID 32745137 · 2020

Mutation Information

gyrB: p.S463A

Protein Change: S463A
Organisms: Salmonella Typhimurium, Salmonella Enteritidis
Confers Resistance To: ciprofloxacin
Validation Method: genomic analysis
Source Database: Reslit

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