ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeD476N

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Overview

Mechanism: Target modification, single resistance variant, DNA topoisomerase IV subunit B ParE
Resistance To: nalidixic acid|ciprofloxacin, fluoroquinolones, quinolones
Organisms: Vibrio cholerae, Escherichia coli
Papers: 2

Paper Information2

Prediction of Antibiotic Susceptibility Profiles of Vibrio cholerae Isolates From Whole Genome Illumina and Nanopore Sequencing Data: CholerAegon.

PMID 35814690 · 2022

The D476N mutation in parE was found in all 80 isolates, but it was not sufficient to confer resistance to NA and CIP in approximately one-quarter of the isolates.

Mutation Information

parE: p.D476N

Protein Change: D476N
Organisms: Vibrio cholerae
Confers Resistance To: nalidixic acid|ciprofloxacin
Validation Method: genomic analysis and phenotypic AST
Source Database: Reslit

Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp.

PMID 25631675 · 2015

Unknown phenotype if D476N occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations

Escherichia coli parE conferring resistance to fluoroquinolones; CARD accession: CARD:3003316

Mutation Information

parE: p.D476N

Protein Change: D476N
Organisms: Escherichia coli
Confers Resistance To: nalidixic acid|ciprofloxacinfluoroquinolones
Effect on Function: Target modification; single resistance variant
Source Database: ResFinder DatabaseCard Database

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