ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneparC

Protein ChangeE84T

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder Database

Overview

Mechanism: Target modification, DNA topoisomerase IV subunit A ParC
Resistance To: nalidixic acid|ciprofloxacin, quinolones
Organisms: Enterococcus faecalis, Enterococcus faecium
Papers: 2

Paper Information2

Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.

PMID 12373497 · 2002

Mutation Information

parC: p.E84T

Protein Change: E84T
Organisms: Enterococcus faecalis, Enterococcus faecium
Confers Resistance To: nalidixic acid|ciprofloxacin
Effect on Function: Target modification
Source Database: ResFinder Database

Alterations in the GyrA subunit of DNA gyrase and the ParC subunit of DNA topoisomerase IV associated with quinolone resistance in Enterococcus faecalis.

PMID 9527801 · 1998

Mutation Information

parC: p.E84T

Protein Change: E84T
Organisms: Enterococcus faecalis, Enterococcus faecium
Confers Resistance To: nalidixic acid|ciprofloxacin
Effect on Function: Target modification
Source Database: ResFinder Database

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