ResLit - Antimicrobial Resistance Gene & Mutation Database

Genecat

chloramphenicol acetyltransferase (CAT)

Protein ChangeH79A

Nucleotide ChangeC235G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: significantly reduces CAT activity and chloramphenicol resistance
Resistance To: phenicols
Organisms: Riemerella anatipestifer, Escherichia coli
Papers: 1

Paper Information1

Type B Chloramphenicol Acetyltransferases Are Responsible for Chloramphenicol Resistance in Riemerella anatipestifer, China.

The H79A substitution significantly reduces CAT activity and chloramphenicol resistance.

Protein Change: H79A
Nucleotide Change: C235G
Organisms: Riemerella anatipestifer, Escherichia coli
Confers Resistance To: phenicols
Effect on Function: significantly reduces CAT activity and chloramphenicol resistance
Validation Method: expression in E. coli BL21 (DE3) cells and in vitro site-directed mutagenesis
Source Database: Reslit

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