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Browse Mutations gyrAL345I

GenegyrA

Protein ChangeL345I

Validation StatusEstablished

Databases

Card Database

Overview

Mechanism: single resistance variant
Resistance To: fluoroquinolones
Organisms: Clostridioides difficile
Papers: 1

Paper Information1

1

Identification of a novel mutation at the primary dimer interface of GyrA conferring fluoroquinolone resistance in Clostridium difficile.

PMID 27842877 · 2015

Clostridioides difficile gyrA conferring resistance to fluoroquinolones; CARD accession: CARD:3003995

Mutation Information

Protein Change: L345I
Organisms: Clostridioides difficile
Confers Resistance To: fluoroquinolones
Effect on Function: single resistance variant
Source Database: Card Database

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research