ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneaxyZ

Protein ChangeV29G

Nucleotide ChangeT86G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: overproduction of the AxyXY-OprZ efflux system
Resistance To: tobramycin|amikacin|gentamicin|netilmicin|ceftazidime|cefepime|imipenem|meropenem|doripenem|ofloxacin|levofloxacin|ciprofloxacin|tetracycline|doxycycline|tigecycline|erythromycin
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Papers: 1

Paper Information1

Role of AxyZ Transcriptional Regulator in Overproduction of AxyXY-OprZ Multidrug Efflux System in Achromobacter Species Mutants Selected by Tobramycin.

PMID 28584156 · 2017

The V29G mutation in AxyZ leads to overproduction of the AxyXY-OprZ efflux system, increasing resistance to multiple antibiotics.

Mutation Information

axyZ: p.V29G / c.T86G

Protein Change: V29G
Nucleotide Change: T86G
Organisms: Achromobacter insuavis, Achromobacter xylosoxidans
Confers Resistance To: tobramycin|amikacin|gentamicin|netilmicin|ceftazidime|cefepime|imipenem|meropenem|doripenem|ofloxacin|levofloxacin|ciprofloxacin|tetracycline|doxycycline|tigecycline|erythromycin
Effect on Function: overproduction of the AxyXY-OprZ efflux system
Validation Method: Mutant analysis and gene expression studies
Source Database: Reslit

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