ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneparC

Protein ChangeT66I

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder DatabaseReslit

Overview

Mechanism: Target modification, DNA topoisomerase IV subunit A ParC
Resistance To: nalidixic acid|ciprofloxacin, quinolones
Organisms: Escherichia coli, Salmonella enterica
Papers: 3

Paper Information3

Quinolone resistance in Escherichia coli from Accra, Ghana.

PMID 21352598 · 2011

Mutation Information

parC: p.T66I / c.C199T

Protein Change: T66I
Nucleotide Change: C199T
Organisms: Escherichia coli
Confers Resistance To: nalidixic acid|ciprofloxacin
Validation Method: sequencing
Source Database: Reslit

Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.

PMID 15388468 · 2004

Mutation Information

parC: p.T66I

Protein Change: T66I
Organisms: Salmonella enterica
Confers Resistance To: nalidixic acid|ciprofloxacin
Effect on Function: Target modification
Source Database: ResFinder Database

Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.

PMID 15848289 · 2005

parC

Mutation Information

parC: p.T66I

Protein Change: T66I
Organisms: Salmonella enterica
Confers Resistance To: quinolones
Effect on Function: DNA topoisomerase IV subunit A ParC
Source Database: Reference Gene Catalog

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