ResLit - Antimicrobial Resistance Gene & Mutation Database

Geneeis

aminoglycoside acetyltransferase

Nucleotide ChangeA-13G

Validation StatusConfirmed2+ DBs

Databases

ResFinder DatabaseReslit

Overview

Paper Information2

Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.

Mutations in the promoter region of eis lead to overexpression of the gene, resulting in kanamycin resistance.

Nucleotide Change: A-13G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: kanamycin
Effect on Function: overexpression of the gene, resulting in kanamycin resistance
Validation Method: Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.
Source Database: Reslit

Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.

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