ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneliaR

transcriptional regulator

Protein ChangeE75K

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: response regulator transcription factor LiaR
Resistance To: daptomycin
Organisms: Enterococcus faecalis, Enterococcus faecium
Papers: 2

Paper Information2

The ionophore resistance genes narA and narB are geographically widespread and linked to resistance to medically important antibiotics.

PMID 40525834 · 2025

Mutation Information

liaR: p.E75K

Protein Change: E75K
Organisms: Enterococcus faecalis, Enterococcus faecium
Confers Resistance To: daptomycin
Validation Method: statistical association with narAB
Source Database: Reslit

Antibiotic resistance determination using Enterococcus faecium whole-genome sequences: a diagnostic accuracy study using genotypic and phenotypic data.

PMID 38219758 · 2024

liaR

Mutation Information

liaR: p.E75K

Protein Change: E75K
Organisms: Enterococcus faecium
Confers Resistance To: daptomycin
Effect on Function: response regulator transcription factor LiaR
Source Database: Reference Gene Catalog

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