Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity.
Substitution of valine at position 612 with phenylalanine increases resistance to linezolid, chloramphenicol, tetracycline, and fluoroquinolones, but decreases resistance to macrolides.
The V612F mutation in AcrB leads to a conformational shift favoring the T state, affecting substrate binding and efflux.
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