Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
ponA penicillin-binding protein 1	L421P	C1262T	increased MIC, decreases penicillin acylation of PBP1 and increases penicillin resistance, reduces penicillin acylation of PBP1 ~3- to 4-fold, penicillin-binding protein 1 PonA	Neisseria gonorrhoeae	cefixime\|ceftriaxoneceftriaxone\|cefiximecefixime\|penicillin+7 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
porA outer membrane protein	-	A-5T	-	Campylobacter coli	-	Reslit	Candidate
porA outer membrane porin	D142H	-	loss of calcium-binding site in channel	Campylobacter jejuni	ciprofloxacin	Reslit	Candidate
porA major outer membrane protein (MOMP)	G56D	-	Efflux, group 2 major outer membrane porin protein PorA	Campylobacter jejuni	ertapenemertapenem\|meropenemcarbapenems	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
porA	ins139D	-	Efflux	Campylobacter jejuni	ertapenem\|meropenem	ResFinder Database	Established
porA	ins139ND	-	Efflux	Campylobacter jejuni	ertapenem\|meropenem	ResFinder Database	Established
porA	N138ND	-	group 2 major outer membrane porin protein PorA	Campylobacter jejuni	carbapenems	Reference Gene Catalog	Established
porB1b outer membrane porin	A121D	-	decreased permeability of antimicrobials, major outer membrane protein porin P.IB	Neisseria gonorrhoeae	ceftriaxone\|cefiximecefiximebeta lactams	Reference Gene CatalogReslit	Confirmed
porB1b outer membrane porin	A121G	-	major outer membrane protein porin P.IB	Neisseria gonorrhoeae	penicillin\|tetracyclinebeta lactams	Reference Gene CatalogReslit	Confirmed
porB1b	A121H	-	major outer membrane protein porin P.IB	Neisseria gonorrhoeae	beta lactams	Reference Gene Catalog	Established