Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	H472R	A1417G	-	Mycobacterium tuberculosis, Mycobacterium leprae, Mycobacterium kansasii	rifampicin	Reslit	Candidate
rpoB beta subunit of RNA polymerase holoenzyme	H476R	-	-	Mycobacterium leprae	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H481C	-	DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus epidermidis	rifampicin	Reference Gene CatalogReslit	Confirmed
rpoB RNA polymerase beta subunit	H481D	C1444G	Target modification, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus aureus	rifampicin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H481F	-	-	Staphylococcus aureus	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H481L	-	-	Staphylococcus aureus, Staphylococcus epidermidis	vancomycinrifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H481N	C1444A CAC->AAC CAG->AAC	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus aureus, Staphylococcus epidermidis	rifampicinvancomycinteicoplanin+1 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H481R	-	-	Staphylococcus aureus	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	H481Y	C1441T C1444T CAG->TAC	increased vancomycin resistance, confers resistance to rifampicin, Target modification, DNA-directed RNA polymerase subunit beta RpoB	Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus epidermidis, Mycobacterium tuberculosis, Staphylococcus lugdunensis, Staphylococcus pseudintermedius	rifampicinvancomycinrifampicin\|vancomycin\|daptomycin	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H482D	-	-	Staphylococcus epidermidis	rifampicin	Reslit	Candidate