Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	H526P	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526Q	-	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526R	CAC-CGC CAC->CGC	had hydrogen bond contact with and electrostatic attraction to the RIF molecule	Mycobacterium tuberculosis, Mycobacterium smegmatis, Rhodococcus equi	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	H526S	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB β subunit of the RNA polymerase	H526T	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB β-subunit of the DNA-dependent RNA polymerase	H526Y	CAC-TAC CAC->TAC C1577T CTG->TAC C1578T C1576T	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Mycobacterium tuberculosis, Escherichia coli, Mycobacterium smegmatis, Rhodococcus equi, Photorhabdus luminescens, M. tuberculosis, Shigella sonnei	rifampicinrifampicin\|rifabutin\|rifapentinerifampicin\|rifabutin+2 more	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	H529Y	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB β-subunit of RNA polymerase	H531C	-	-	Pseudomonas fluorescens, Pseudomonas aeruginosa	rifampicin	Reslit	Candidate
rpoB RNA polymerase β-chain	H531L	A1592T	-	Pseudomonas aeruginosa, Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB	H531R	A1592G	-	Mycobacterium tuberculosis, Pseudomonas aeruginosa	rifampicin	Reslit	Candidate