Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	S531E	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531F	TCA -> TTC TCA->TTC	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Escherichia coli, Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium gastri, Shigella sonnei	rifampicin\|rifabutin\|rifapentinerifampicinrifamycins	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	S531H	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531K	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531L	TCA->CTA TCG-TTG TCT -> CTT TCA -> TTC AGT->CTT AGC->CTC TCC->CTC	disrupted the intermolecular hydrogen bond between wild-type Ser531 and the RIF molecule, reduces susceptibility, disorders the RIF-binding pocket upon RMP binding and therefore reduces the binding affinity for RMP	Mycobacterium tuberculosis, Mycobacterium simiae, Mycobacterium smegmatis, Rhodococcus equi, Escherichia coli, Mycobacterium avium, Salmonella enterica, Mycobacterium bovis	rifampicinrifampicin\|rifabutinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	S531P	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531Q	TCA->CAA	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531R	-	-	-	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531T	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	S531W	C1593G TCA->TGA TCG-TGG	-	Mycobacterium tuberculosis, Mycobacterium smegmatis, Rhodococcus equi, Mycobacterium avium	rifampicinrifampicin\|rifabutin	Reslit	Supported