Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	T518S	-	-	Staphylococcus aureus	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T525D	-	enhances rifampicin binding	Escherichia coli	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta-subunit	T525N	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T539A	-	-	Helicobacter pylori	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T54A	-	-	Mycobacterium tuberculosis	ofloxacin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T563P	-	Target modification, single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Escherichia coli, Shigella sonnei	rifampicin\|rifabutin\|rifapentinerifampicinrifamycins	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	T593A	-	-	Helicobacter pylori	rifabutin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T593K	-	-	Helicobacter pylori	rifabutin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T622I	-	-	Staphylococcus aureus	oxacillin	Reslit	Candidate
rpoB RNA polymerase beta subunit	T634K	-	upregulation of a previously uncharacterized operon (prdRAB) that leads to cell membrane remodelling and cross-resistance to daptomycin through reduced binding of the antibiotic	Enterococcus faecium	daptomycin	Reslit	Candidate