Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
thyA thymidylate synthase | E58Q | - | - | Escherichia coli | trimethoprim sulfamethoxazole | Reslit | Candidate |
| F152V | - | single resistance variant | Mycobacterium tuberculosis | para aminosalicylic acid | Card DatabaseResFinder Database | Confirmed | |
thyA thymidylate synthase | F176L | - | - | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
thyA thymidylate synthase | F231Y | - | - | Staphylococcus aureus | trimethoprim sulfamethoxazole | Reslit | Candidate |
| G76* | - | - | Mycobacterium tuberculosis | para aminosalicylic acid | ResFinder Database | Established | |
| G76Ter | - | nonsense mutation | Mycobacterium tuberculosis | para aminosalicylic acid | Card Database | Established | |
| G91R | - | single resistance variant | Mycobacterium tuberculosis | para aminosalicylic acid | Card DatabaseResFinder Database | Confirmed | |
| H207R | - | single resistance variant | Mycobacterium tuberculosis | para aminosalicylic acid | Card DatabaseResFinder Database | Confirmed | |
thyA thymidylate synthase | H75N | - | single resistance variant | Mycobacterium tuberculosis | para aminosalicylic acid | Card DatabaseResFinder DatabaseReslit | Confirmed |
thyA Thymidylate synthase A | L143P | - | The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms. | Mycobacterium tuberculosis | para aminosalicylic acid | Reslit | Candidate |
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