Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
thyA thymidylate synthase	Q124K	-	-	Staphylococcus aureus	trimethoprim sulfamethoxazole	Reslit	Candidate
thyA thymidylate synthase	Q97R	-	-	Mycobacterium tuberculosis	para aminosalicylic acid	Reslit	Candidate
thyA	R126Q	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder Database	Confirmed
thyA Thymidylate synthase A	R127L	-	The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.	Mycobacterium tuberculosis	para aminosalicylic acid	Reslit	Candidate
thyA	R222G	-	-	Mycobacterium tuberculosis	para aminosalicylic acid	ResFinder Database	Established
thyA thymidylate synthase	R235P	C703T	loss of function, single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder DatabaseReslit	Confirmed
thyA	S105P	-	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acid	Card DatabaseResFinder Database	Confirmed
thyA thymidylate synthase	S125F	-	-	Mycobacterium tuberculosis	para aminosalicylic acid	Reslit	Candidate
thyA thymidylate synthase	T202A	ACT->GCC	single resistance variant	Mycobacterium tuberculosis	para aminosalicylic acidpyrazinamide	Card DatabaseReslit	Confirmed
thyA dihydrofolate reductase	T22A	-	single resistance variant	Mycobacterium tuberculosis	paspara aminosalicylic acid	Card DatabaseResFinder DatabaseReslit	Confirmed