Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
Rv0678 repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression | L43P | - | - | - | clofaziminebedaquiline|clofazimine | Reslit | Candidate |
Rv0678 transcription repressor for efflux pump MmpL5 | L43R | - | - | - | clofaziminebedaquiline|clofazimine | Reslit | Candidate |
Rv0678 transcriptional inhibitor of the efflux pump MmpS5-MmpL5 | L44P | - | Mycobacterium tuberculosis | bedaquilineclofaziminebedaquiline|clofazimine | Reslit | Supported | |
Rv0678 repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression | L56P | - | - | - | clofazimine | Reslit | Candidate |
Rv0678 transcriptional repressor of the MmpS5-MmpL5 efflux system | L74P | - | - | - | bedaquiline|clofazimine | Reslit | Candidate |
Rv0678 repressor protein that regulates mmpS5/mmpL5 efflux pump gene expression | M139R | - | - | - | bedaquiline|clofazimine | Reslit | Candidate |
Rv0678 efflux pump component | M139T | - | - | Mycobacterium tuberculosis | bedaquiline|clofazimine | Reslit | Candidate |
Rv0678 repressor of the MmpS5-MmpL5 efflux pump | M146T | single resistance variant | Mycobacterium tuberculosis | bedaquiline|clofaziminebedaquilineclofazimine | Card DatabaseReslit | Confirmed | |
| N70D | - | single resistance variant | Mycobacterium tuberculosis | bedaquilineclofazimine | Card Database | Established | |
Rv0678 repressor of the MmpS5-MmpL5 efflux pump | N98D | - | Mycobacterium tuberculosis | bedaquiline|clofazimine | Reslit | Candidate |
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