Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA topoisomerase IV subunit A	H103Y	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA DNA gyrase subunit A	I45M	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus	ciprofloxacinciprofloxacin\|levofloxacin\|moxifloxacin	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV subunit A	K23N	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	N327K	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P157L	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P451L	-	-	-	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	P451S	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	R43C	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	R85Q	-	-	-	ciprofloxacin	Reslit	Candidate
grlA DNA topoisomerase IV subunit A	S143P	-	-	Staphylococcus aureus	ciprofloxacin	Reslit	Candidate