Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
grlA DNA gyrase subunit A	S144P	-	-	-	ciprofloxacin	Reslit	Candidate
grlA topoisomerase IV subunit A	S52R	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate
grlA	S80F	AGT -> TTC G240T A239G C241T	reduced the potency of ciprofloxacin, mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin, resistance, confers resistance to fluoroquinolones, mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones, Target modification	Staphylococcus aureus, Streptococcus pneumoniae, S. epidermidis, S. haemolyticus, S. arlettae, S. simulans, S. saprophyticus, S. borealis, S. sciuri, S. hominis, S. pasteuri, S. hyicus	quinolonesciprofloxacinfluoroquinolones+11 more	ResFinder DatabaseReslit	Confirmed
grlA DNA gyrase subunit A	S80G	-	-	Staphylococcus coagulans	ciprofloxacin\|moxifloxacin	Reslit	Candidate
grlA topoisomerase IV A subunit	S80I	TCA->ATA	DNA topoisomerase GrlA	Staphylococcus pseudintermedius, Staphylococcus coagulans, Staphylococcus aureus, Staphylococcus intermedius	enrofloxacinciprofloxacinenrofloxacin\|ciprofloxacin\|moxifloxacin+2 more	Reference Gene CatalogReslit	Confirmed
grlA DNA topoisomerase IV A subunit	S80L	TCT->CTT	-	Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus aureus	ciprofloxacin	Reslit	Supported
grlA DNA gyrase subunit A	S80R	-	DNA topoisomerase GrlA	Staphylococcus coagulans, Staphylococcus pseudintermedius, Staphylococcus intermedius	enrofloxacinfluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
grlA topoisomerase IV subunit A	S80Y	G240T AGT->TAT	mutations in grlA (Ser80→Phe or Tyr) were most commonly selected with trovafloxacin, ciprofloxacin, levofloxacin, or pefloxacin, Target modification	Staphylococcus aureus	fluoroquinolonesnorfloxacinciprofloxacin\|moxifloxacin+4 more	ResFinder DatabaseReslit	Confirmed
grlA topoisomerase IV subunit A	S81F	-	enhances single-stranded DNA cleavage and suppresses double-stranded DNA breaks	Bacillus anthracis, Escherichia coli	fluoroquinolonesciprofloxacin	Reslit	Supported
grlA topoisomerase IV subunit A	S81P	-	mutations result in the synthesis of proteins with reduced susceptibility or insensitivity to fluoroquinolones	Staphylococcus aureus	ciprofloxacin\|levofloxacin\|moxifloxacin	Reslit	Candidate