Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
gyrA DNA gyrase	A88N	-	-	Helicobacter pylori	levofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	A88P	-	single resistance variant	Corynebacterium amycolatum, Corynebacterium striatum, Corynebacterium spp., Helicobacter pylori	ciprofloxacin\|levofloxacin\|moxifloxacinfluoroquinoloneslevofloxacin	Card DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	A88V	-	-	Helicobacter pylori, Corynebacterium spp.	fluoroquinolonesciprofloxacin\|gatifloxacin\|levofloxacinlevofloxacin	Reslit	Supported
gyrA DNA gyrase subunit A	A908T	-	-	Pseudomonas aeruginosa	ciprofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	A90A	-	-	Mycobacterium tuberculosis	fluoroquinolonesofloxacin	Reslit	Candidate
gyrA DNA gyrase subunit A	A90E	-	-	Mycobacterium tuberculosis	fluoroquinolonesofloxacin\|moxifloxacin	ResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	A90G	-	single resistance variant	Mycobacterium tuberculosis	quinolonesfluoroquinolonesofloxacin\|moxifloxacin	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	A90S	-	mutant A90S contributes to both intrinsic and acquired quinolone resistance	Mycobacterium tuberculosis	fluoroquinolones	Reslit	Candidate
gyrA DNA gyrase subunit A	A90V	GCC->GTC G268T C270T GCA->GTG C269T GCA->GTT G269T	mutations in the gyrA and/or gyrB subunit of DNA gyrase lead to fluoroquinolone resistance, confers resistance, disrupting the water-metal ion bridge, steric hindrance impairing LVX interaction with GyrA catalytic site, alter the protein at codons 90, replacing alanine with valine, single resistance variant, multiple resistance variants, co-dependent single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium smegmatis, Bacillus anthracis, Escherichia coli	fluoroquinolonesofloxacinciprofloxacin+23 more	Card DatabaseResFinder DatabaseReslit	Confirmed
gyrA DNA gyrase subunit A	A91P	-	-	Mycobacterium leprae	ofloxacin	Reslit	Candidate