Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
katG	S303C	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Established
katG	S303L	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card Database	Established
katG ketoacyl-ACP synthase III	S315A	-	-	Mycobacterium tuberculosis	isoniazid	Reslit	Candidate
katG Enoyl-(acyl-carrier-protein) reductase	S315F	-	-	-	isoniazid	Reslit	Candidate
katG catalase-peroxidase	S315G	-	loss of catalase-peroxidase activity, single resistance variant	Mycobacterium tuberculosis	isoniazidprothionamide	Card DatabaseReslit	Confirmed
katG catalase-peroxidase	S315I	-	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card DatabaseReslit	Confirmed
katG catalase-peroxidase	S315L	-	-	Mycobacterium tuberculosis	isoniazid	Reslit	Supported
katG ketoacyl-ACP synthase III	S315N	A944G C944T	single resistance variant	Mycobacterium tuberculosis	isoniazidprothionamide	Card DatabaseReslit	Confirmed
katG catalase-peroxidase	S315R	A944C	single resistance variant	Mycobacterium tuberculosis	isoniazid	Card DatabaseReslit	Confirmed
katG catalase-peroxidase	S315T	T943C C943T G944C A944T TGG > ACT AGC-ACC C944T G946C A943T T945A GGA->ACC C944G C943G T943A T947A TCA -> ACT AGC->ACC T944A T944G	confers resistance, results in an enzyme without the ability to activate isoniazid, but retains approximately 50% of its catalase-peroxidase activity, The katG Ser315Thr alteration results in an enzyme that cannot activate INH but that still maintains significant catalase-peroxidase activity, thus permitting the INH-resistant organism to survive in the presence of oxidative stress., mutations in katG, in particular at codon 315 (katG315), are commonly observed to cause resistance to INH, profoundly decrease INH activation and result in drug resistance, resistance to isoniazid, loss of catalase-peroxidase activity, high-level drug resistance, reduced catalytic activity, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium simiae, M. bovis, human, M. tuberculosis	isoniazidrifampicinisoniazid\|ethambutol+1 more	Card DatabaseReslit	Confirmed