Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
mprF large membrane protein with 14 transmembrane domains	I420N	-	gain-in-function, single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed
mprF phosphatidylglycerol lysyltransferase	I427F	-	-	-	daptomycin	Reslit	Candidate
mprF Phospholipid flippase	L341F	-	increased daptomycin MIC	Staphylococcus aureus	daptomycin	Reslit	Candidate
mprF lysylphosphatidylglycerol synthetase	L341S	T1022C C1021T	single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed
mprF phosphatidylglycerol lysyltransferase	L425F	-	-	methicillin-resistant Staphylococcus	daptomycin	Reslit	Candidate
mprF	L431F	-	bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus	daptomycin\|vancomycin	Reference Gene Catalog	Established
mprF lipid lysyl transferase	L826F	C2477T	gain-in-function, single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed
mprF	M347R	-	single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus	daptomycin	Card DatabaseReference Gene Catalog	Confirmed
mprF lysyl-phosphatidylglycerol synthase	N553D	-	-	Pseudomonas aeruginosa	polymyxin b\|colistin	Reslit	Candidate
mprF L-PG synthase	P314L	C941T	single resistance variant, bifunctional lysylphosphatidylglycerol flippase/synthetase MprF	Staphylococcus aureus, methicillin-resistant Staphylococcus	daptomycin	Card DatabaseReference Gene CatalogReslit	Confirmed