Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
nalC nalC	E153Q	-	mutations in regulators MexR, NalC, or NalD	Pseudomonas aeruginosa	levofloxacin\|ciprofloxacingentamicinciprofloxacin+1 more	Reslit	Supported
nalC negatively regulates the multidrug efflux pump MexAB-OprM	F55C	-	-	Pseudomonas aeruginosa	cefiderocol	Reslit	Candidate
nalC efflux pump regulator	G123D	-	-	Pseudomonas aeruginosa	quinolones\|beta lactams	Reslit	Candidate
nalC transcriptional regulator NalC	G125D	-	mutations in nalC lead to the overexpression of mexAB-oprM, efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	meropenemaztreonam	Reference Gene CatalogReslit	Confirmed
nalC transcriptional regulator	G71E	-	mutations in regulators MexR, NalC, or NalD, up-regulate the mexAB-oprM operon, efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	aztreonam\|carbenicillin\|piperacillin tazobactam\|meropenemcarbapenemsciprofloxacin+7 more	Reference Gene CatalogReslit	Confirmed
nalC	K58E	-	efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	carbapenems	Reference Gene Catalog	Established
nalC	S127P	-	efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	carbapenems	Reference Gene Catalog	Established
nalC transcriptional regulator	S209R	-	mutations in regulators MexR, NalC, or NalD, up-regulate the mexAB-oprM operon, efflux system transcriptional repressor NalC	Pseudomonas aeruginosa	carbapenemsciprofloxacinfluoroquinolones\|cephalosporins\|aminoglycosides+4 more	Reference Gene CatalogReslit	Confirmed
nalC nalC	S46A	-	-	Pseudomonas aeruginosa	levofloxacin	Reslit	Candidate
nalD transcriptional regulator	-	397–398del	-	-	fluoroquinolones\|tetracycline\|phenicols\|macrolides	Reslit	Candidate