Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
| Gene | Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|---|
nfsA nitroreductase | W46R | - | - | Escherichia coli | nitrofurantoin | Reslit | Candidate |
nfsB nitrofurantoin reductase | A155G | - | - | - | nitrofurantoin | Reslit | Candidate |
nfsB nitrofurantoin reductase | A19T | - | - | - | nitrofurantoin | Reslit | Candidate |
nfsB nitroreductase | D198Y | - | modification or loss of NfsB is a well-known mechanism of nitrofurantoin resistance in E. coli, leading to inactivated or poor catalytic function, oxygen-insensitive NAD(P)H nitroreductase NfsB | Klebsiella pneumoniae | nitrofurantoin | Reference Gene CatalogReslit | Confirmed |
nfsB nitrofurantoin reductase | D25E | - | - | - | nitrofurantoin | Reslit | Candidate |
| E137Ter | - | nonsense mutation | Escherichia coli | nitrofurantoin | Card Database | Established | |
| E197Ter | - | oxygen-insensitive NAD(P)H nitroreductase NfsB | Escherichia coli | nitrofurantoin | Reference Gene Catalog | Established | |
nfsB nitroreductase | E75* | - | - | Escherichia coli | nitrofurantoin | Reslit | Candidate |
nfsB nitroreductase | F84S | - | oxygen-insensitive NAD(P)H nitroreductase NfsB | Escherichia coli | nitrofurantoin | Reference Gene CatalogReslit | Confirmed |
nfsB nitroreductase | G126R | - | - | Escherichia coli | nitrofurantoin | Reslit | Candidate |
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