Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
amgS histidine kinase sensor	A203V	-	mutations in the linker domain of AmgS, the closest Escherichia coli homolog of AmgS, often cause activation of the kinase sensor	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
amgS sensor kinase	C28A	-	-	Pseudomonas aeruginosa	tobramycin	Reslit	Candidate
amgS putative ABC transporter	E108Q	-	-	Pseudomonas aeruginosa	amikacin	Reslit	Candidate
amgS histidine kinase sensor	P116L	-	mutations in the sensor domain of AmgS, where mutations involved in aminoglycoside resistance have been previously described	Pseudomonas aeruginosa	aminoglycosides	Reslit	Candidate
amgS	P381S	-	two-component system sensor histidine kinase AmgS	Pseudomonas aeruginosa	carbapenems	Reference Gene Catalog	Established
amgS glucosamine-6-phosphate synthase	P435A	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
amgS sensor component of the AmgRS two-component system	R182C	-	gain-of-function mutation that activates the AmgRS two-component system, two-component system sensor histidine kinase AmgS	Pseudomonas aeruginosa	tobramycin\|gentamicin\|amikacin\|paromomycin\|neomycin\|streptomycinamikacin\|tobramycin	Reference Gene CatalogReslit	Confirmed
amgS sensor kinase	V121G	-	increased mexXY expression, two-component system sensor histidine kinase AmgS	Pseudomonas aeruginosa	tobramycin\|gentamicin\|amikacinamikacin\|tobramycin	Reference Gene CatalogReslit	Confirmed
amgS glucosamine-6-phosphate synthase	W120G	-	-	Pseudomonas aeruginosa	colistin	Reslit	Candidate
amiC N-acetylmuramoyl-L-alanine amidase	-	G1204A	-	-	imipenem	Reslit	Candidate