Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
parE DNA topoisomerase IV	S457T	-	DNA topoisomerase IV subunit B ParE	Pseudomonas aeruginosa	fluoroquinolonesquinolones	Reference Gene CatalogReslit	Confirmed
parE topoisomerase IV subunit B	S458A	T1373G T1374G	resistance, Target modification, DNA topoisomerase IV subunit B ParE	Haemophilus influenzae, Escherichia coli, Shigella flexneri, Salmonella Typhimurium, Klebsiella pneumoniae, E. coli, Klebsiella spp.	fluoroquinolonesciprofloxacinenrofloxacin+11 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit E	S458E	-	-	Escherichia coli	enrofloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit B	S458F	-	-	-	enrofloxacin	Reslit	Candidate
parE DNA topoisomerase IV subunit E	S458L	-	DNA topoisomerase IV subunit B ParE	Shigella flexneri, Escherichia coli	fluoroquinolonesnalidixic acid\|ciprofloxacinciprofloxacin\|levofloxacin+1 more	Reference Gene CatalogReslit	Confirmed
parE DNA topoisomerase IV subunit E	S458P	-	Target modification, DNA topoisomerase IV subunit B ParE	Salmonella enterica, Salmonella	ciprofloxacin\|nalidixic acidciprofloxacinciprofloxacin\|ofloxacin\|sparfloxacin\|levofloxacin\|moxifloxacin\|gemifloxacin+2 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit B	S458T	TCA -> ACC T1373A	Target modification, DNA topoisomerase IV subunit B ParE	Escherichia coli	norfloxacin\|ciprofloxacinciprofloxacinciprofloxacin\|nalidixic acid+4 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
parE DNA topoisomerase IV subunit E	S464F	TCT->TTC	-	Escherichia coli, Enterobacter cloacae, Citrobacter freundii	ciprofloxacin\|levofloxacinciprofloxacin\|nalidixic acid	Reslit	Candidate
parE DNA topoisomerase IV subunit B	S465L	-	-	Stenotrophomonas maltophilia	ciprofloxacin	Reslit	Candidate
parE topoisomerase IV subunit	S468F	-	-	Pseudomonas aeruginosa	ciprofloxacin\|garenoxacin	Reslit	Candidate