Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pbp1b penicillin-binding protein 1B	S160A	-	-	Streptococcus agalactiae	penicillin\|cefotaxime	Reslit	Candidate
pbp1b penicillin-binding protein	T491N	-	shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac	Enterococcus faecalis	vancomycin	Reslit	Candidate
pbp1b penicillin-binding protein 1B	V80A	-	-	Streptococcus agalactiae	penicillin\|cefotaxime	Reslit	Candidate
pbp2 penicillin-binding protein 2	A172T	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
pbp2 penicillin-binding protein 2	A285P	G854C	-	Staphylococcus aureus	oxacillin	Reslit	Candidate
pbp2	A296V	-	single resistance variant	Helicobacter pylori	amoxicillin	Card Database	Established
pbp2 penicillin-binding protein 2	A311V	-	lower affinity for ceftriaxone and restrict conformational changes that normally accompany acylation, single resistance variant	Neisseria gonorrhoeae	ceftazidime\|ceftriaxonebeta lactams	Card DatabaseReslit	Confirmed
pbp2 penicillin-binding protein 2	A420V	-	-	Staphylococcus aureus	vancomycin	Reslit	Candidate
pbp2 penicillin-binding protein 2	A450D	-	reduced affinity for β-lactams	Staphylococcus aureus	oxacillin	Reslit	Candidate
pbp2 penicillin-binding protein 2	A501P	-	single resistance variant	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximebeta lactams	Card DatabaseReslit	Confirmed