Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
penA Penicillin-Binding Protein 2	A501P	-	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximecefixime\|ceftriaxonecefixime+3 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	A501R	-	-	Neisseria gonorrhoeae	cefixime\|ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	A501S	-	-	Neisseria gonorrhoeae	cefixime\|ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	A501T	-	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	cefixime\|ceftriaxoneceftriaxone\|cefotaximeceftriaxone\|cefixime+6 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA penicillin-binding protein 2	A501V	-	increased resistance, reduced reactivity for β-lactams, decreased susceptibility to cefixime and ceftriaxone, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	cefixime\|ceftriaxoneceftriaxone\|cefiximeceftriaxone\|cefotaxime+6 more	Reference Gene CatalogResFinder DatabaseReslit	Confirmed
penA Penicillin-Binding Protein 2	A510V	T1532C	reduced reactivity for β-lactams, penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae, Neisseria meningitidis	ceftriaxone\|cefiximepenicillincefixime+5 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	A516G	T1549G	penicillin-binding protein PBP2 PenA	Neisseria gonorrhoeae	cefiximepenicillin\|cephalosporinsceftriaxone+3 more	Reference Gene CatalogReslit	Confirmed
penA penicillin-binding protein 2	A517G	-	-	-	ceftriaxone\|cefixime	Reslit	Candidate
penA penicillin-binding protein 2	A549T	-	-	Neisseria gonorrhoeae	ceftriaxone	Reslit	Candidate
penA penicillin-binding protein 2	A574V	-	-	-	cefixime	Reslit	Candidate