Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
pncA pyrazinamidase	K45K	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
pncA	K48E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	K48N	-	-	Mycobacterium tuberculosis	pyrazinamide	Reslit	Candidate
pncA pyrazinamidase	K48T	A144G	loss of PZAse activity, loss of activity, susceptible, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA	K48Ter	-	nonsense mutation	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA	K96E	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA	K96M	-	single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card Database	Established
pncA pyrazinamidase	K96N	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	K96Q	A286C	disrupts catalytic activity, single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	pyrazinamide	Card DatabaseReslit	Confirmed
pncA pyrazinamidase	K96R	-	reduced binding affinity of PZA to PZase, single resistance variant	Mycobacterium tuberculosis	pyrazinamide	Card DatabaseReslit	Confirmed