Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB RNA polymerase beta subunit	D172G	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB subunit β of the RNA polymerase (RNAP)	D203E	GAT->GAA C610G	-	Pseudomonas aeruginosa	ceftazidime\|rifampicinceftazidime	Reslit	Candidate
rpoB beta subunit of RNA polymerase	D342G	-	mutations in specific positions of the coding sequences are known to affect the binding of drugs to RNAP, leading to drug resistance	Escherichia coli	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D427V	-	-	Streptomyces diastatochromogenes	rifampicin	Reslit	Candidate
rpoB DNA-directed RNA polymerase subunit beta	D432G	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D435A	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	D435E	-	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	D435F	-	single resistance variant	Mycobacterium tuberculosis, Mycobacterium bovis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA-polymerase beta-subunit	D435G	GAC->GGC A1305G G1303C	single resistance variant	Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis	rifampicincapreomycinrifampicin\|rifabutin+1 more	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	D435H	-	single resistance variant	Mycobacterium bovis, Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed