Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D435K	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB	D435L	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	D435N	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB	D435T	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	D435V	GAT->GTT A1305T G1303T A1306T G1305T A1304T	substitutes the negatively charged aspartate with a bulkier nonpolar valine residue causing steric hindrance within the rifampicin-binding pocket, increased IC 50 of both rifamycins, single resistance variant, multiple resistance variants	Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium bovis, Escherichia coli	rifampicincapreomycinrifampicin\|rifabutin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB	D435Var	-	single resistance variant	Mycobacterium tuberculosis	rifampicin	Card Database	Established
rpoB RNA polymerase beta subunit	D435X	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA-polymerase beta-subunit	D435Y	G1305T G1304T G1303T	single resistance variant, multiple resistance variants	Mycobacterium tuberculosis	rifampicin	Card DatabaseResFinder DatabaseReslit	Confirmed
rpoB RNA polymerase beta subunit	D441A	-	loss of interactions with drug except Gly438, Phe439 and Arg465	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D441C	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate