Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

Gene	Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
rpoB	D492N	-	single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Clostridium ljungdahlii, Clostridioides difficile	rifampicinrifaximin	Card DatabaseReference Gene Catalog	Confirmed
rpoB DNA-directed RNA polymerase beta subunit	D492V	-	single resistance variant, DNA-directed RNA polymerase subunit beta RpoB	Clostridium difficile, Clostridium ljungdahlii, Clostridioides difficile	rifampicin\|rifaximinrifampicinrifaximin	Card DatabaseReference Gene CatalogReslit	Confirmed
rpoB	D492Y	-	DNA-directed RNA polymerase subunit beta RpoB	Clostridioides difficile	rifaximin	Reference Gene Catalog	Established
rpoB RNA polymerase beta subunit	D516A	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	D516E	-	-	Mycobacterium tuberculosis, Mycobacterium smegmatis	rifampicinrifabutin	Reslit	Supported
rpoB RNA polymerase beta subunit	D516F	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Supported
rpoB RNA polymerase beta subunit	D516G	A1548G G1547A	DNA-directed RNA polymerase subunit beta RpoB	Mycobacterium tuberculosis, Escherichia coli, E. coli, Pseudomonas aeruginosa, Pseudomonas fluorescens, Mycobacterium smegmatis, Salmonella enterica, Shigella sonnei	rifampicinrifabutin	Reference Gene CatalogReslit	Confirmed
rpoB β subunit of RNA polymerase	D516H	-	-	Mycobacterium smegmatis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D516L	-	-	Mycobacterium tuberculosis	rifampicin	Reslit	Candidate
rpoB RNA polymerase beta subunit	D516N	-	-	Escherichia coli, Mycobacterium smegmatis, Mycobacterium tuberculosis	rifampicin\|rifabutin\|rifapentinerifampicin	Reslit	Supported